Description

4-Bromo-2,3-Difluorophenylacetonitrile is a high-value, multi-functional aromatic nitrile building block used in advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on the phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the difluorophenyl moiety.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating specialized fluorinated compounds used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl and conjugated systems.
• Functional Material Research: Employed in the development of polymers, ligands for catalysis, and other advanced materials requiring specific fluorinated aromatic units.

Basic Information

Product Name	4-Bromo-2,3-Difluorophenylacetonitrile
CAS No.	1627857-25-3
Molecular Formula	C8H4BrF2N
Molecular Weight	232.03 g/mol
Synonyms	2-(4-Bromo-2,3-difluorophenyl)acetonitrile; (4-Bromo-2,3-difluorophenyl)acetonitrile; 4-Bromo-2,3-difluorobenzeneacetonitrile; 2,3-Difluoro-4-bromophenylacetonitrile; α-Cyano-4-bromo-2,3-difluorotoluene; 4-Bromo-2,3-difluoro-α-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.