Description

(R)-2-Hydroxy-3-(Diphenylphosphino)-2’-[(S)-Hydroxy(Phenyl)Methyl]-[1,1’-Binaphthalene] is a sophisticated, chiral bidentate ligand belonging to the BINOL-derived phosphine family, crucial for enabling highly selective asymmetric catalytic transformations. Its value lies in its ability to induce exceptional enantioselectivity in key bond-forming reactions, directly impacting the efficiency and purity of advanced chemical synthesis. This high-performance ligand is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Catalyzes key reactions such as Rhodium-catalyzed 1,4-additions and Palladium-catalyzed cross-couplings with high stereoselectivity.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates for therapeutic areas including oncology, CNS disorders, and infectious diseases.
• Agrochemical Active Ingredient Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Employed to develop scalable, cost-effective, and high-yielding manufacturing routes for complex chiral molecules.

Basic Information

Product Name	(R)-2-Hydroxy-3-(Diphenylphosphino)-2’-[(S)-Hydroxy(Phenyl)Methyl]-[1,1’-Binaphthalene]
CAS No.	1621627-47-1
Molecular Formula	C39H29O2P
Molecular Weight	560.62 g/mol
Synonyms	(R)-2-Hydroxy-3-(diphenylphosphino)-2'-[(S)-hydroxy(phenyl)methyl]-1,1'-binaphthalene; (R)-2-Hydroxy-3-(diphenylphosphino)-2'-[(S)-hydroxy(phenyl)methyl]-[1,1'-binaphthyl]; BINOL-Derived Chiral Phosphine Ligand; (R,S)-BINOL-PHOX Hybrid Ligand; CAS 1621627-47-1; Chiral Bidentate P,O-Ligand; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management protocols to ensure consistent high purity and performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC assay), and identity confirmation. Our quality systems support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at 2-8°C under an inert atmosphere (argon or nitrogen) in a desiccated environment to prevent oxidation and moisture absorption. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.