Description

Bromosporine CAS NO 1619994-69-2 is a potent and selective small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins. This compound matters as a critical research tool for epigenetics and oncology studies, enabling the investigation of gene regulation and transcriptional control pathways. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for cancer, inflammatory diseases, and other conditions driven by epigenetic dysregulation.

Application

• Biochemical Research: A key tool compound for studying BET protein function, chromatin remodeling, and epigenetic signaling in vitro.
• Oncology Research: Used in target validation and mechanistic studies for cancers where BET proteins play a role, such as leukemia, lymphoma, and solid tumors.
• Drug Discovery: Serves as a lead compound or a pharmacological probe in high-throughput screening and hit-to-lead optimization campaigns for novel BET inhibitors.
• Inflammatory Disease Models: Applied in research exploring the role of BET proteins in regulating inflammatory gene expression, relevant to conditions like rheumatoid arthritis and sepsis.
• Cellular Pathway Analysis: Utilized to dissect specific gene regulatory networks and transcriptional dependencies in various cell types.
• Preclinical Studies: Employed in animal models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of BET inhibition.

Basic Information

Product Name	Bromosporine
CAS No.	1619994-69-2
Molecular Formula	C₂₃H₂₀BrN₅O₂
Molecular Weight	478.34 g/mol
Synonyms	Bromosporine; 3-Methyl-5-(2-(4-(methylsulfonyl)piperazin-1-yl)-4-(thiophen-2-yl)phenyl)isoxazole; Bromosporine (BET inhibitor); BET Bromodomain Inhibitor Bromosporine; Bromosporine, >=98% (HPLC); CC-90002; GTPL11034
EINECS	Contact for details

Quality Control

Our Bromosporine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and quality is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.