Description

Dbco-(Ch2)2-Nh2-Co-(Ch2)2Cooh CAS NO 1618102-42-3 is a heterobifunctional crosslinker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a primary amine for further conjugation via carboxylic acid groups. This compound is critical for creating stable, catalyst-free bioconjugates in complex biological systems. It is primarily needed by researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science for labeling, immobilization, and polymer functionalization.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: For site-specific labeling of proteins, antibodies, and peptides via the amine-reactive carboxylic acid, followed by SPAAC click chemistry with azide-modified payloads.
• Diagnostic Probe and Biosensor Fabrication: Immobilization of biomolecules onto surfaces (e.g., chips, nanoparticles, microarrays) for creating sensitive detection platforms.
• Polymer and Biomaterial Functionalization: Introducing bio-orthogonal click chemistry handles into hydrogels, dendrimers, and other polymeric structures for tissue engineering or drug delivery systems.
• Chemical Biology and Proteomics: As a key reagent for metabolic labeling, activity-based protein profiling, and the study of biomolecular interactions in live cells.
• Nanoparticle and Liposome Modification: Conjugating targeting ligands or imaging agents to nanocarriers for targeted therapy and diagnostics (theranostics).
• Small Molecule Library Synthesis: Facilitating the rapid and efficient synthesis of compound libraries through sequential amine and click chemistry reactions.

Basic Information

Item	Detail
Product Name	Dbco-(Ch2)2-Nh2-Co-(Ch2)2Cooh
CAS No.	1618102-42-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DBCO-PEG2-Amine; DBCO-PEG2-NH2; DBCO-C2-Amine; DBCO-C2-NH2; 1-(DBCO-PEG2)-ethylamine; Dibenzocyclooctyne-PEG2-Amine; (Azadibenzocyclooctyne)-PEG2-Amine; N-(2-(2-(3-(4-(1,2,4,5-Tetrazin-3-yl)phenyl)-1,2,4,5-tetrazin-3-yl)ethoxy)ethyl)acetamide (related structural analog)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR and/or MS), and other critical parameters are available upon request. We adhere to a cGMP-compliant quality management system for traceability and reproducibility, essential for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Assay	≥ 90% active

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.