Description

2-Chloro-5-Fluoro-4-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially in creating biaryl and heterobiaryl structures common in many therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated aromatic motifs.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and liquid crystal displays (LCDs).
• Chemical Biology & Diagnostics: Employed in the development of molecular probes, sensors, and bioconjugation reagents due to its selective reactivity.
• Catalyst & Ligand Development: Utilized in the preparation of novel palladium catalyst ligands to optimize cross-coupling reaction efficiency.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific boronic acid components.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Methylphenylboronic Acid
CAS No.	1612184-35-6
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-5-fluoro-4-methylphenyl)boronic acid; 2-Chloro-5-fluoro-p-tolylboronic acid; 4-Methyl-2-chloro-5-fluorobenzeneboronic acid; B-(2-Chloro-5-fluoro-4-methylphenyl)boronic acid; 2-Chloro-5-fluoro-4-methylbenzeneboronic acid; 1612184-35-6; Boronic acid, B-(2-chloro-5-fluoro-4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Methylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and quality assurance for your R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.