Description

Carbonic Acid, 4-Nitrophenyl 3-(2-Pyridinyldithio)Propyl Ester is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and chemical biology applications. Its core value lies in its dual functionality, featuring a cleavable disulfide linkage and an activated carbonate ester, enabling controlled and reversible coupling of biomolecules. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require precise and reversible protein modification or drug-antibody conjugation strategies.

Application

• Bioconjugation Reagent: For the controlled, reversible crosslinking of proteins, peptides, and antibodies via disulfide bond formation.
• ADC (Antibody-Drug Conjugate) Linker Development: Serves as a cleavable linker platform in the synthesis of targeted cancer therapeutics.
• Affinity Chromatography Ligand Synthesis: Used to immobilize ligands onto solid supports for protein purification.
• Surface Functionalization: Modifying nanoparticles, biosensors, and other materials with bioactive molecules.
• Proteomics Research: A tool for studying protein-protein interactions and structural analysis through reversible crosslinking.
• Diagnostic Reagent Manufacturing: Key component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays.

Basic Information

Product Name	Carbonic Acid, 4-Nitrophenyl 3-(2-Pyridinyldithio)Propyl Ester
CAS No.	1610731-08-2
Molecular Formula	C15H12N2O5S2
Molecular Weight	364.40 g/mol
Synonyms	3-(2-Pyridinyldithio)propyl 4-nitrophenyl carbonate; 4-Nitrophenyl 3-(2-pyridyldithio)propyl carbonate; SPPC; PDP Carbonate; Heterobifunctional Crosslinker SPPC; 3-(Pyridin-2-yldisulfanyl)propyl (4-nitrophenyl) carbonate; 2-Pyridyldithiopropyl 4-nitrophenyl carbonate
EINECS	Contact for details

Quality Control

Our Carbonic Acid, 4-Nitrophenyl 3-(2-Pyridinyldithio)Propyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.