Description

tert-Butyl trans-3-Amino-4-Hydroxy-1-Pyrrolidinecarboxylate Hydrochloride is a high-purity, protected pyrrolidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold with orthogonal protecting groups, enabling precise stereochemical control in complex molecule assembly. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other biologically active molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Peptidomimetics & Constrained Peptides: The pyrrolidine core is integral for designing conformationally restricted peptide analogs to improve metabolic stability and binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	tert-Butyl trans-3-Amino-4-Hydroxy-1-Pyrrolidinecarboxylate Hydrochloride
CAS No.	1609403-41-9
Molecular Formula	C9H19ClN2O3
Molecular Weight	238.71 g/mol
Synonyms	tert-Butyl (3R,4S)-3-Amino-4-hydroxypyrrolidine-1-carboxylate hydrochloride; (3R,4S)-1-Boc-3-amino-4-hydroxypyrrolidine hydrochloride; trans-1-Boc-3-amino-4-hydroxypyrrolidine HCl; (3R,4S)-3-Amino-4-hydroxy-N-Boc-pyrrolidine hydrochloride; 1-Boc-3-amino-4-hydroxypyrrolidine hydrochloride; 1-(tert-Butoxycarbonyl)-3-amino-4-hydroxypyrrolidine HCl; (3R,4S)-1-(tert-Butoxycarbonyl)-3-amino-4-hydroxypyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our production of tert-Butyl trans-3-Amino-4-Hydroxy-1-Pyrrolidinecarboxylate Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications, which typically include chiral purity, chemical purity, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.