Description

2-Amino-4-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound featuring both an amino and a trifluoromethyl group on the aromatic ring. This unique structure makes it a highly valuable building block in modern synthetic chemistry, particularly for the creation of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing new active ingredients, especially those requiring the metabolic stability and lipophilicity imparted by the trifluoromethyl group.

Application

• Pharmaceutical Intermediate: A key synthon for constructing biaryl structures found in active pharmaceutical ingredients (APIs), particularly in drug discovery for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF₃ group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for synthesizing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for specialty polymers.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate ligands for transition metal catalysis.
• Chemical Biology Probes: Useful for creating boronic acid-based sensors and probes for detecting sugars or other biological analytes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific boronic acid derivative.

Basic Information

Product Name	2-Amino-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1604034-81-2
Molecular Formula	C₇H₇BF₃NO₂
Molecular Weight	204.95 g/mol
Synonyms	2-Amino-4-(trifluoromethyl)benzeneboronic acid; [2-Amino-4-(trifluoromethyl)phenyl]boronic acid; 2-Amino-α,α,α-trifluoro-p-tolueneboronic acid; B-[2-Amino-4-(trifluoromethyl)phenyl]boronic acid; 2-Amino-4-trifluoromethylphenylboronic acid; 4-Trifluoromethyl-2-aminophenylboronic acid; 2-Amino-4-CF3-phenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(Trifluoromethyl)Phenylboronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR for structural confirmation, and elemental analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.