Description

(R)-tert-Butyl 3-Methyl-5-Oxopiperidine-1-Carboxylate is a high-purity chiral piperidinone derivative, serving as a critical advanced pharmaceutical intermediate. Its primary value lies in enabling the synthesis of complex, stereochemically defined active pharmaceutical ingredients (APIs), particularly in chiral drug development. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Chiral Auxiliary/Synthon: Used in asymmetric synthesis to introduce the (R)-configured stereocenter into more complex molecular architectures.
• API Development: Serves as a precursor in the research and scale-up production of specific active pharmaceutical ingredients requiring the 3-methyl-5-oxopiperidine scaffold.
• Agrochemical Synthesis: Intermediate for developing advanced, stereoselective agrochemicals such as herbicides and fungicides.
• Academic & Contract Research: Used in university and CRO laboratories for methodological development in organic and medicinal chemistry.
• Process Chemistry: Employed in route scouting and optimization for the commercial manufacturing of chiral compounds.

Basic Information

Product Name	(R)-tert-Butyl 3-Methyl-5-Oxopiperidine-1-Carboxylate
CAS No.	1601475-90-4
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	1-Boc-3-methyl-5-piperidinone (R-enantiomer); (R)-1-(tert-Butoxycarbonyl)-3-methylpiperidin-5-one; (R)-3-Methyl-5-oxo-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl (R)-3-methyl-5-oxopiperidine-1-carboxylate; (R)-N-Boc-3-methyl-5-piperidone; (R)-3-Methyl-5-piperidinone, 1-Boc protected; (R)-1-N-Boc-3-methyl-5-piperidone
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-Methyl-5-Oxopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.