Description

2-Fluoro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with fluorinated aromatic motifs, enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated biphenyl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLED emitters and charge-transport materials, where the boronic ester group facilitates precise molecular assembly.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands and metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Cross-Coupling Methodology Development: A standard reagent in academic and industrial laboratories for optimizing and scaling Suzuki-Miyaura coupling reactions under challenging conditions.

Basic Information

Product Name	2-Fluoro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1599432-39-9
Molecular Formula	C₁₃H₁₅BF₄O₂
Molecular Weight	290.07 g/mol
Synonyms	2-Fluoro-6-(trifluoromethyl)benzeneboronic acid pinacol ester; (2-Fluoro-6-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-6-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 2-(2-Fluoro-6-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 2-Fluoro-6-(trifluoromethyl)phenylboronate; Boronic acid, B-[2-fluoro-6-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); 2-Fluoro-6-trifluoromethylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.