Description

2-(2-Chloro-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific halogenated aromatic frameworks.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: A specialized reagent for palladium-catalyzed Suzuki-Miyaura couplings, facilitating carbon-carbon bond formation under mild conditions.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries.
• Ligand and Catalyst Preparation: Useful in the synthesis of specialized ligands and organometallic catalysts.

Basic Information

Product Name	2-(2-Chloro-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1599432-38-8
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	2-(2-Chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Chloro-6-fluorophenyl)boronic acid pinacol ester; 2-Chloro-6-fluorophenylboronic acid pinacol ester; Pinacol (2-chloro-6-fluorophenyl)boronate; 2-Chloro-6-fluorobenzeneboronic acid pinacol ester; 1599432-38-8; B-(2-Chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-6-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical: 98-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.