Description

[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]Phenylmethyl]-2-Methyl-2-Propanesulfinamide CAS NO 1595319-99-5 is a high-value, chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. Its primary value lies in its ability to act as a highly effective and selective ligand for transition metal catalysts, enabling the production of enantiomerically pure compounds. This makes it an indispensable material for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for rhodium, iridium, and ruthenium catalysts in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Cross-Coupling Reactions: Used in asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to create complex chiral architectures.
• Agrochemical Development: Enables the synthesis of enantiomerically pure herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic pathways in academic laboratories and corporate R&D centers.
• Fine Chemical Production: For the manufacture of specialty flavors, fragrances, and advanced materials where chirality dictates functional properties.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]Phenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1595319-99-5
Molecular Formula	C29H42NOPS
Molecular Weight	483.70 g/mol
Synonyms	(SR)-N-[(S)-[2-(Dicyclohexylphosphino)phenyl](phenyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[2-(Dicyclohexylphosphino)phenyl](phenyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (SR,S)-t-Bu-Sulfinamide-DCPhos; (SR,S)-N-(2-(Dicyclohexylphosphino)benzylidene)-2-methylpropane-2-sulfinamide derivative; Hybrid P,N-Ligand; Asymmetric Hydrogenation Ligand; CAS 1595319-99-5
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral ligand is produced and tested under strict quality control protocols to ensure consistency and performance in sensitive catalytic applications. Our standard grade typically meets a purity specification of ≥97% (HPLC), with rigorous chiral purity verification. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, identity (IR, NMR), and residual solvent levels is provided with each shipment. Specifications can be customized to meet specific research or cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The material is moisture-sensitive; ensure the container is sealed in a dry environment. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.