Description

[S(R)]-n-[(S)-[2-(Diphenylphosphino)Phenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide CAS NO 1595319-95-1 is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value specialty chemical for advanced synthetic chemistry. Its core value lies in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereocontrol in catalytic asymmetric synthesis.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand in transition-metal catalyzed reactions, including asymmetric hydrogenation, cross-coupling, and C-H activation.
• Pharmaceutical Intermediate Synthesis: Critical for the enantioselective construction of complex molecular scaffolds in the development of novel therapeutics and APIs.
• Agrochemical Research: Used in the synthesis of chiral active ingredients for herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Methodology Development: A key tool for academic and industrial researchers developing new catalytic asymmetric methodologies in organic synthesis.
• Fine Chemical Production: Enables the commercial-scale manufacture of enantiomerically pure flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Diphenylphosphino)Phenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1595319-95-1
Molecular Formula	C34H32NOPS
Molecular Weight	533.66 g/mol
Synonyms	(S)-N-((S)-1-([1,1'-Biphenyl]-2-yl)-1-(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide; (S)-N-((S)-1-([1,1'-Biphenyl]-2-yl)-1-(1-naphthyl)methyl)-2-methylpropane-2-sulfinamide; (S)-N-((S)-1-([1,1'-Biphenyl]-2-yl)-1-(1-naphthyl)methyl)-2-methyl-2-propanesulfinamide; (S)-N-((S)-1-([1,1'-Biphenyl]-2-yl)-1-(naphthalen-1-yl)methyl)-2-methylpropane-2-sulfinamide; (S)-N-((S)-1-([1,1'-Biphenyl]-2-yl)-1-(1-naphthyl)methyl)-2-methyl-2-propanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; P,N-Ligand; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality system is designed to support cGMP and ISO standards for advanced chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade its catalytic efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.