Description

(S(R))-N-[(1R)-1-[2-(Diphenylphosphino)Phenyl]Ethyl]-2-Methyl-2-Propanesulfinamide CAS NO 1595319-89-3 is a high-purity, chiral sulfinamide-phosphine hybrid ligand, a critical building block in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition-metal catalyzed reactions, including hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: Key reagent in the synthesis of enantiomerically pure drug candidates and complex natural products.
• Agrochemical Research: Used in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Methodology Development: A valuable tool for academic and industrial research into new asymmetric synthetic methodologies.
• Ligand Library Construction: Serves as a sophisticated component for creating diverse ligand libraries for high-throughput catalyst screening.

Basic Information

Product Name	(S(R))-N-[(1R)-1-[2-(Diphenylphosphino)Phenyl]Ethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1595319-89-3
Molecular Formula	C24H28NOPS
Molecular Weight	409.52 g/mol
Synonyms	(SR)-N-[(1R)-1-[2-(Diphenylphosphino)phenyl]ethyl]-2-methylpropane-2-sulfinamide; (R)-1-[(S)-tert-Butylsulfinyl]-N-[2-(diphenylphosphino)phenyl]ethylamine; Chiral Sulfinamide-Phosphine Ligand; (SR,R)-JOSIPHOS-type Sulfinamide Ligand; tert-Butanesulfinamide, N-[(1R)-1-[2-(diphenylphosphino)phenyl]ethyl]-, (S)-; (S)-N-((R)-1-(2-(Diphenylphosphino)phenyl)ethyl)-2-methylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Every batch of (S(R))-N-[(1R)-1-[2-(Diphenylphosphino)Phenyl]Ethyl]-2-Methyl-2-Propanesulfinamide undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced synthetic applications. Our quality assurance protocol includes comprehensive characterization to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.