Description

2-Bromo-4,5-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for modern cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic systems. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used to create novel fluorinated herbicides, fungicides, and pesticides with enhanced biological activity and environmental stability.
• Material Science Research: Serves as a building block for developing organic light-emitting diodes (OLEDs), liquid crystals, and other fluorinated functional polymers.
• Chemical Biology & Diagnostics: Employed in the synthesis of fluorinated probes, tags, and molecular scaffolds for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Suitable for route development and optimization from milligram to kilogram scale in GMP and non-GMP environments.
• Academic & Contract Research: A critical reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	2-Bromo-4,5-Difluorophenylboronic Acid Pinacol Ester
CAS No.	1595078-09-3
Molecular Formula	C₁₂H₁₄BBrF₂O₂
Molecular Weight	303.95 g/mol
Synonyms	(2-Bromo-4,5-difluorophenyl)boronic acid pinacol ester; 2-Bromo-4,5-difluorobenzeneboronic acid pinacol ester; 4,5-Difluoro-2-bromophenylboronic acid pinacol ester; Pinacol (2-bromo-4,5-difluorophenyl)boronate; 2-Bromo-4,5-difluorophenyl-Bpin; B-(2-Bromo-4,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1595078-09-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and lot-to-lot consistency. Certificates of Analysis (COA) with full spectral data are provided for all shipments, supporting cGMP and ISO 9001 compliance for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and light-sensitive nature. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.