Description

cis-[2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl](2-Methylphenyl)Nickel(II) Chloride is a highly specialized organometallic complex featuring a chiral BINAP-derived ligand, designed for advanced catalytic applications. This compound matters for its role as a precise and efficient catalyst in asymmetric synthesis, enabling the production of enantiomerically pure intermediates critical for high-value chemical manufacturing. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel synthetic routes and optimize existing ones.

Application

• Asymmetric Catalysis: A key precursor for nickel-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Negishi couplings, to form C-C bonds with high enantioselectivity.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral active pharmaceutical ingredients (APIs) and complex molecular scaffolds under mild conditions.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Investigated for the synthesis of chiral polymers and advanced organic electronic materials.
• Academic & Industrial R&D: Serves as a critical tool for methodological development in organic synthesis and catalysis research.
• Fine Chemical Production: Applied in the manufacture of specialty flavors, fragrances, and other high-purity chiral compounds.

Basic Information

Product Name	cis-[2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl](2-Methylphenyl)Nickel(II) Chloride
CAS No.	1594113-05-9
Molecular Formula	C51H40ClNiP2
Molecular Weight	806.96 g/mol
Synonyms	(R)- or (S)-Ni(BINAP)(o-Tolyl)Cl; Nickel(II) (2-methylphenyl)[(R)- or (S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl] chloride; (o-Tolyl)NiCl(BINAP); BINAP-Ni(o-Tolyl)Cl; Chiral Nickel BINAP Complex; Asymmetric Nickel Catalyst; (2-Methylphenyl)nickel(II) chloride complex with BINAP; Nickel(II) chloride complex with 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and 2-methylphenyl
EINECS	Contact for details

Quality Control

Every batch of our organometallic catalysts is produced and tested under strict inert atmosphere conditions to guarantee purity and catalytic activity. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify chemical identity, chiral purity, and absence of critical impurities. Certificates of Analysis (COA) detailing lot-specific results are provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dedicated freezer. This compound is strictly light-sensitive, easily oxidized, and hygroscopic. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Red-brown to dark brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R or S isomer)
Elemental Analysis (Ni)	Theoretical ± 0.5%
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.