Description

(R)-3-[(E)-[[(S)-1-[2-(Diphenylphosphino)Phenyl]Ethyl]Imino]Methyl]-[1,1’-Binaphthalene]-2,2’-Diol is a sophisticated chiral ligand belonging to the BINOL-phosphine-oxazoline hybrid class, designed for high-performance asymmetric catalysis. Its core value lies in enabling exceptional enantioselectivity and catalytic efficiency in critical carbon-carbon and carbon-heteroatom bond-forming reactions. This advanced ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel chiral active ingredients and intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Catalyzes reactions such as Rhodium-catalyzed 1,4-additions and Palladium-catalyzed allylic alkylations with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drugs, including β-blockers, antifungal agents, and antiviral compounds.
• Agrochemical Synthesis: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Applied in the synthesis of complex, high-value chiral molecules for flavors, fragrances, and specialty materials.
• Academic and Process R&D: A valuable tool for methodology development and optimization of catalytic cycles in research laboratories.
• Catalyst Library Development: Serves as a key component in screening libraries for discovering new asymmetric transformations.

Basic Information

Item	Details
Product Name	(R)-3-[(E)-[[(S)-1-[2-(Diphenylphosphino)Phenyl]Ethyl]Imino]Methyl]-[1,1’-Binaphthalene]-2,2’-Diol
CAS No.	1582249-48-6
Molecular Formula	C41H32NO2P
Molecular Weight	601.67 g/mol
Synonyms	(R)-3-[(E)-[[(S)-1-[2-(Diphenylphosphino)phenyl]ethyl]imino]methyl]-[1,1'-binaphthalene]-2,2'-diol; (R)-3-[(E)-[[(S)-1-[2-(Diphenylphosphino)phenyl]ethyl]imino]methyl]-2,2'-dihydroxy-1,1'-binaphthyl; BINOL-Derived P,N-Ligand; Chiral Phosphino-Oxazoline Ligand; Asymmetric Hydrogenation Ligand CAS 1582249-48-6
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our quality systems support development under cGMP guidelines for pharmaceutical applications, and we comply with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.