Description

8-Bromooct-1-Yn-3-Ol CAS NO 1579278-86-6 is a versatile bifunctional organic building block featuring both a terminal alkyne and a bromoalkyl chain, separated by an alcohol group. This unique structure makes it a critical intermediate for the synthesis of complex molecules through cross-coupling reactions and click chemistry. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing molecular scaffolds and functionalized polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for introducing alkyne handles for bioconjugation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require specific alkyl-alkyne motifs.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for creating functional polymers, dendrimers, and smart materials with tailored properties.
• Click Chemistry Reagent: The terminal alkyne group is ideal for Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) to create triazole linkages.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Organic Synthesis Building Block: Utilized in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to construct complex organic architectures.
• Bioconjugation and Probe Synthesis: Facilitates the labeling of biomolecules (proteins, peptides, nucleic acids) with fluorescent or affinity tags for diagnostic applications.

Basic Information

Product Name	8-Bromooct-1-Yn-3-Ol
CAS No.	1579278-86-6
Molecular Formula	C₈H₁₃BrO
Molecular Weight	205.09 g/mol
Synonyms	8-Bromo-1-octyn-3-ol; 3-Octyn-1-ol, 8-bromo-; 8-Bromo-3-octyn-1-ol; 1-Octyn-3-ol, 8-bromo-; Bromooctynol; 8-Bromooct-1-yn-3-ol; 1579278-86-6; 8-Bromo-1-octyne-3-ol
EINECS	Contact for details

Quality Control

Our 8-Bromooct-1-Yn-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.