Description

Palbociclib-029 is a high-purity pharmaceutical intermediate and reference standard, identified by CAS NO 1566082-34-5. This compound is a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the oncology therapeutic area. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development and production of targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor in the manufacture of Palbociclib and related CDK4/6 inhibitor APIs.
• Reference Standard: Serves as a certified standard for quality control (QC) and analytical method development in pharmaceutical laboratories.
• Research & Development: Used in medicinal chemistry research for the discovery and optimization of novel kinase inhibitor compounds.
• Process Development: Employed in scaling up and optimizing synthetic routes for commercial pharmaceutical production.
• Regulatory Submissions: Provides essential impurity markers and characterization data for drug master files (DMFs) and regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	Palbociclib-029
CAS No.	1566082-34-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one; Palbociclib Impurity; Palbociclib Related Compound; CDK4/6 Inhibitor Intermediate; IBRANCE Impurity; PD-0332991 Intermediate
EINECS	Contact for details

Quality Control

Our Palbociclib-029 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) that detail all test results against established specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.