Description

Fmoc-D-Cys(Phacm)-Oh is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide orthogonal protection for the cysteine thiol group during solid-phase peptide assembly, preventing unwanted side reactions. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating complex peptides, peptidomimetics, and bioconjugates with high structural fidelity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled incorporation of D-cysteine into peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Research: Synthesis of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Building block for creating stable, drug-like molecules that mimic natural peptides.
• Bioconjugation: Enables site-specific attachment of payloads (e.g., drugs, dyes, polymers) to peptides or proteins via the protected thiol handle.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme activity.
• GPCR Ligand Development: Critical for constructing disulfide-rich peptides that target G-protein-coupled receptors.

Basic Information

Product Name	Fmoc-D-Cys(Phacm)-Oh
CAS No.	1565818-55-4
Molecular Formula	C27H26N2O5S
Molecular Weight	490.57 g/mol
Synonyms	Fmoc-D-Cys(Phacm)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-cysteine(Phacm); Fmoc-D-Cysteine(Phacm)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((phenylamino)carbothioylthio)propanoic acid; D-Fmoc-Cys(Phacm)-OH; Fmoc-D-Cys(PhAcM)-OH; Nα-Fmoc-Nβ-(phenylacetamidomethyl)-D-cysteine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Cys(Phacm)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports applications in GMP-compliant research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the CoA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.