Description

2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile, 2-[(2S)-2-Amino-2-(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Acetyl]-, (1S,3R,5S)- is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined bicyclic and tricyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new drugs targeting the central nervous system, metabolic disorders, and other complex disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The structural motifs suggest potential application in the design of inhibitors for specific enzymatic targets.
• Neurological Drug Candidates: Serves as a precursor for compounds targeting GPCRs or ion channels relevant to CNS disorders.
• Asymmetric Synthesis: Utilized in chiral pool synthesis or as a starting material for generating libraries of enantiomerically pure compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile, 2-[(2S)-2-Amino-2-(3-Hydroxytricyclo[3.3.1.13,7]Dec-1-Yl)Acetyl]-, (1S,3R,5S)-
CAS No.	1564266-00-7
Molecular Formula	C18H23N3O2
Molecular Weight	313.40 g/mol
Synonyms	(1S,3R,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-, (1S,3R,5S)-; (1S,3R,5S)-2-((S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Advanced Pharmaceutical Intermediate 1564266-00-7; Adamantyl-substituted azabicyclohexane carbonitrile derivative.
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess, NMR, and mass spectrometry for structural confirmation, and stringent purity assays. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.