Description

Boc-D-Meglu(Obzl)-Oh is a protected amino acid derivative, specifically a Boc-protected form of D-glutamic acid with a benzyl ester side chain. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, diagnostic probes, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Solid-Phase Peptide Synthesis (SPPS): Used for the controlled, sequential incorporation of D-glutamic acid into custom peptide sequences, enabling the creation of peptides with enhanced stability or specific biological activity.
• Bioconjugation and Probe Development: Serves as a precursor for labeling reagents and linkers in antibody-drug conjugates (ADCs) or imaging agents, where the protected functional groups allow for selective modification.
• Academic and R&D Laboratories: Employed in fundamental research exploring protein structure-function relationships, peptide self-assembly, and the development of new synthetic methodologies.
• Production of Protected Peptide Fragments: Used to synthesize specific, protected segments of larger target peptides or proteins in solution-phase chemistry.

Basic Information

Product Name	Boc-D-Meglu(Obzl)-Oh
CAS No.	1562452-07-6
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Boc-D-Glu(OBzl)-OH; (2R)-5-(Benzyloxy)-2-{[(2-methylpropan-2-yl)oxy]carbonyl}amino}-5-oxopentanoic acid; N-(tert-Butoxycarbonyl)-D-glutamic acid 5-benzyl ester; Boc-D-Glutamic acid 5-benzyl ester; Boc-D-Glu(OBn)-OH; tert-Butoxycarbonyl-D-glutamic acid γ-benzyl ester; D-Glutamic acid, N-(1,1-dimethylethoxy)carbonyl-, 5-benzyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Meglu(Obzl)-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), chiral purity, appearance, and identification is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Melting Point	Contact for details
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.