Description

(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid is a sophisticated, optically active Fmoc-protected amino acid derivative. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the controlled introduction of specific side-chain functionalities. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and advanced chemical synthesis laboratories for the development of novel peptide-based therapeutics and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected amino acid monomer for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including hormone analogs, enzyme inhibitors, and targeted biologics.
• Bioconjugation: Acts as a precursor for creating peptide-drug conjugates or for labeling peptides with probes and tags.
• Chemical Biology: Employed in the synthesis of peptide libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Academic Research: Essential for university and institutional labs studying protein-protein interactions, signal transduction, and peptide chemistry.
• Custom Peptide Manufacturing: A vital raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	(R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid
CAS No.	1562442-35-6
Molecular Formula	C25H29NO6
Molecular Weight	439.50 g/mol
Synonyms	Fmoc-N-Me-γ-tBu-D-Glu-OH; Fmoc-N-methyl-D-glutamic acid 5-tert-butyl ester; (R)-5-(tert-Butoxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-5-oxopentanoic acid; N-α-Fmoc-N-α-methyl-D-glutamic acid γ-tert-butyl ester; Fmoc-N-Me-D-Glu(OtBu)-OH; N-Fmoc-N-methyl-D-glutamic acid 5-tert-butyl ester; Fmoc-N-methyl-D-glutamic acid γ-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-glutamic acid 1-tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of (R)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid adheres to stringent quality protocols suitable for pharmaceutical research applications. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.