Description

Fmoc-n-α-(4-Aminobenzoyl)-L-Glutamic Acid CAS NO 1562435-65-7 is a high-purity, protected amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block for introducing the L-glutamic acid moiety with a photolabile or cleavable protecting group, enabling precise control in solid-phase peptide synthesis (SPPS). It is essential for researchers and manufacturers in the fields of medicinal chemistry, bioconjugation, and the development of novel therapeutic peptides and antibody-drug conjugates (ADCs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of L-glutamic acid into peptide chains.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals and prodrugs.
• Antibody-Drug Conjugate (ADC) Development: Serves as a linker-payload component for constructing targeted cancer therapies.
• Bioconjugation: Facilitates the site-specific attachment of peptides to proteins, surfaces, or other biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptides.
• Proteomics Research: Used in the synthesis of specialized peptide probes and standards.

Basic Information

Product Name	Fmoc-n-α-(4-Aminobenzoyl)-L-Glutamic Acid
CAS No.	1562435-65-7
Molecular Formula	C27H24N2O7
Molecular Weight	488.49 g/mol
Synonyms	Fmoc-Abz-L-Glu-OH; N-α-Fmoc-N-γ-(4-aminobenzoyl)-L-glutamic acid; Fmoc-L-Glu(4-Abz)-OH; 9-Fluorenylmethyl N-{N-[4-(aminocarbonyl)benzoyl]-L-α-glutamyl}carbamate; Fmoc-Glu(4-Abz)-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-(4-aminobenzamido)pentanedioic acid; Fmoc-L-glutamic acid 4-aminobenzoyl derivative
EINECS	Contact for details

Quality Control

Our Fmoc-n-α-(4-Aminobenzoyl)-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.