Description

Di-Fmoc-n-α-Aminomethyl-L-Alanine is a specialized, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound is engineered to provide superior control over the incorporation of the unique aminomethyl-alanine moiety, enabling the construction of complex peptide architectures and peptidomimetics. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, peptide-based therapeutics, and molecular probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled introduction of the aminomethyl-alanine residue into peptide chains.
• Peptidomimetic Drug Discovery: Used to synthesize and screen peptide analogs with enhanced stability, bioavailability, and target affinity.
• Conjugation Chemistry: The orthogonal Fmoc protection allows for selective deprotection, facilitating site-specific conjugation with labels, linkers, or other biomolecules.
• Combinatorial Library Synthesis: Enables the rapid generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Research & Development: Serves as a critical reagent in academic and industrial R&D for studying protein-protein interactions and developing new bioactive peptides.
• API Intermediate Production: Acts as a high-purity starting material or intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs).

Basic Information

Item	Details
Product Name	Di-Fmoc-n-α-Aminomethyl-L-Alanine
CAS No.	1562433-56-0
Molecular Formula	C35H32N2O6
Molecular Weight	576.64 g/mol
Synonyms	N,N-Bis(9H-fluoren-9-ylmethoxycarbonyl)-L-2,3-diaminopropanoic acid; (S)-2,3-Bis((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid; Fmoc-Aminomethyl-L-Alanine-OH; Di-Fmoc-L-Dap-OH; Nα,Nβ-Bis-Fmoc-L-2,3-diaminopropionic acid; L-2,3-Diaminopropionic acid, N,N-bis(9-fluorenylmethoxycarbonyl)-; Di-Fmoc-L-2,3-diaminopropanoic acid
EINECS	Contact for details

Quality Control

Our Di-Fmoc-n-α-Aminomethyl-L-Alanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.