Description

Fmoc-(S)-2-Amino-3-Ethoxypropionic Acid CAS NO 1562432-09-0 is a protected, non-proteinogenic amino acid derivative featuring an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine and an ethoxy side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides with modified or engineered properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral intermediate for incorporating the non-natural amino acid (S)-2-amino-3-ethoxypropionic acid into custom peptide sequences.
• Pharmaceutical R&D: For the discovery and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug conjugates.
• Peptidomimetic Design: Used to create peptide analogs with enhanced metabolic stability, bioavailability, or receptor selectivity by introducing an ether-containing side chain.
• Bioconjugation & Probe Synthesis: Serves as a building block for synthesizing labeled peptides or peptide-based imaging agents and diagnostic tools.
• Academic Research: Employed in biochemical and biophysical studies to investigate protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new bioactive compounds.

Basic Information

Product Name	Fmoc-(S)-2-Amino-3-Ethoxypropionic Acid
CAS No.	1562432-09-0
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	Fmoc-AeProp-OH; Fmoc-(S)-2-Amino-3-ethoxypropanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-ethoxy-L-alanine; (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-ethoxypropanoic acid; Fmoc-L-2-amino-3-ethoxypropionic acid; N-Fmoc-3-ethoxy-L-alanine; Fmoc-3-ethoxy-L-Ala-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Amino-3-Ethoxypropionic Acid is manufactured under controlled conditions to ensure high chemical purity and chiral integrity, meeting the stringent requirements of peptide synthesis. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral HPLC for enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.