Description

2,4-Difluoro-3-Iodo-1,5-Dimethoxybenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring iodine and fluorine atoms on a dimethoxybenzene scaffold, makes it a versatile precursor for constructing complex molecules via cross-coupling and nucleophilic substitution reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and pesticides with enhanced activity and selectivity.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of advanced polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine moiety is an excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions to form biaryl and other conjugated systems.
• Nucleophilic Aromatic Substitution: The fluorine atoms provide reactive sites for substitution with various nucleophiles, enabling further functionalization.

Basic Information

Product Name	2,4-Difluoro-3-Iodo-1,5-Dimethoxybenzene
CAS No.	1560796-27-1
Molecular Formula	C8H7F2IO2
Molecular Weight	300.04 g/mol
Synonyms	1,5-Dimethoxy-2,4-difluoro-3-iodobenzene; 3-Iodo-2,4-difluoro-1,5-dimethoxybenzene; Benzene, 2,4-difluoro-3-iodo-1,5-dimethoxy-; 1560796-27-1
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Iodo-1,5-Dimethoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.