Description

3-Fluorocyclobutane-1-Carbonitrile is a high-value, fluorinated cyclobutane derivative serving as a critical building block in advanced organic synthesis. Its unique structure, combining a strained cyclobutane ring with fluorine and nitrile functional groups, makes it an essential intermediate for developing novel pharmaceuticals and agrochemicals. This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated cyclobutyl motifs into their molecular designs.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs exploring fluorinated analogs to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorocyclobutyl group can enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts in asymmetric synthesis.
• Material Science Precursor: Potential building block for advanced polymers and liquid crystals, leveraging the rigidity of the cyclobutane ring.
• Fluorine Chemistry Library Synthesis: A valuable scaffold for constructing diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	3-Fluorocyclobutane-1-Carbonitrile
CAS No.	1552638-51-3
Molecular Formula	C5H6FN
Molecular Weight	99.11 g/mol
Synonyms	3-Fluorocyclobutanecarbonitrile; 3-Fluorocyclobutyl cyanide; (3-Fluorocyclobutyl)carbonitrile; 1-Cyano-3-fluorocyclobutane; Fluorocyclobutanecarbonitrile; 3-Fluoro-1-cyanocyclobutane; Cyclobutane-1-carbonitrile, 3-fluoro-; 1552638-51-3
EINECS	Contact for details

Quality Control

Our 3-Fluorocyclobutane-1-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable performance in your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.