Description

2-(2,4-Dichlorophenyl)-2,2-Difluoroacetic Acid is a high-value, multi-functional fluorinated aromatic building block. This compound matters as a critical synthetic intermediate, enabling the introduction of a difluoroacetic acid moiety into complex molecular architectures, which is essential for modulating the physicochemical and biological properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoroacetate group can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Advanced Material Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties imparted by the fluorine and chlorine atoms.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes and tags for studying enzyme mechanisms and protein interactions in biochemical research.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(2,4-Dichlorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1552586-81-8
Molecular Formula	C8H4Cl2F2O2
Molecular Weight	241.02 g/mol
Synonyms	2,2-Difluoro-2-(2,4-dichlorophenyl)acetic Acid; α,α-Difluoro-2,4-dichlorophenylacetic Acid; 2,4-Dichloro-α,α-difluorophenylacetic Acid; (2,4-Dichlorophenyl)difluoroacetic Acid; Difluoro(2,4-dichlorophenyl)acetic Acid; 2-(2,4-Dichlorophenyl)-2,2-difluoroethanoic Acid
EINECS	Contact for details

Quality Control

Our 2-(2,4-Dichlorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for full traceability and lot-to-lot verification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.