Description

4-(1,1-Difluoroethyl)-α-Methyl-Benzenemethanamine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluoroethyl-substituted benzylamine structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small-molecule drugs, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor for novel pesticides and herbicides, leveraging the fluorine atoms for enhanced biological activity and environmental stability.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials where the difluoroethyl group imparts specific physicochemical properties.
• Chemical Biology & Proteomics: Employed as a building block for creating molecular probes and tool compounds for biological target identification and validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of complex organic molecules in a GMP or non-GMP environment.

Basic Information

Product Name	4-(1,1-Difluoroethyl)-α-Methyl-Benzenemethanamine
CAS No.	1551427-73-6
Molecular Formula	C11H15F2N
Molecular Weight	199.24 g/mol
Synonyms	α-Methyl-4-(1,1-difluoroethyl)benzylamine; 1-[4-(1,1-Difluoroethyl)phenyl]ethanamine; Benzenemethanamine, 4-(1,1-difluoroethyl)-α-methyl-; 4-(1,1-Difluoroethyl)-α-methylbenzenemethanamine; (RS)-1-[4-(1,1-Difluoroethyl)phenyl]ethanamine; 1-(4-(1,1-Difluoroethyl)phenyl)ethan-1-amine
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)-α-Methyl-Benzenemethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, and we support regulatory documentation for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.