Description

Benzeneacetic Acid, α-(1,1-Dimethylethyl)-2-Fluoro- is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical sector where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the fluorinated moiety enhances lipophilicity and target binding.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or precursor for developing fluorinated polymers with unique thermal, chemical, or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	Benzeneacetic Acid, α-(1,1-Dimethylethyl)-2-Fluoro-
CAS No.	1551243-06-1
Molecular Formula	C12H15FO2
Molecular Weight	210.25 g/mol
Synonyms	2-Fluoro-α-(tert-butyl)phenylacetic acid; 2-Fluoro-α-tert-butylbenzeneacetic acid; α-tert-Butyl-2-fluorophenylacetic acid; (2-Fluorophenyl)(tert-butyl)acetic acid; tert-Butyl(2-fluorophenyl)acetic acid; 2-(tert-Butyl)-2-(2-fluorophenyl)acetic acid; [2-(tert-Butyl)-2-(2-fluorophenyl)]acetic acid
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, α-(1,1-Dimethylethyl)-2-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.