Description

(-)-1,13-Bis[Di(4-Methylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Tol-Skp is a high-purity, chiral phosphine ligand essential for asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is specifically needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance ligands for complex synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic synthesis of chiral building blocks for active pharmaceutical ingredients (APIs), including those for cardiovascular, central nervous system, and antiviral drugs.
• Agrochemical Manufacturing: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Can be employed as a supporting ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to enhance selectivity.
• Academic & Process R&D: A valuable tool for developing new catalytic methodologies and optimizing synthetic pathways in laboratory and pilot-scale research.
• Fine Chemical Production: Enables the commercial synthesis of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Item	Detail
Product Name	(-)-1,13-Bis[Di(4-Methylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Tol-Skp
CAS No.	1548897-80-8
Molecular Formula	C51H49O2P2
Molecular Weight	746.88 g/mol
Synonyms	(S,S,S)-(-)-Tol-Skp; (S,S,S)-(-)-Tol-Skewphos; (S,S,S)-(-)-Tol-BINAP Analog; (5As,8As,14As)-(-)-1,13-Bis[bis(4-methylphenyl)phosphino]-5a,6,7,8,8a,9-hexahydro-5H-dibenzo[d,h][1,3,2]dioxaphosphepine; Chiral Phosphine Ligand L*; Skewphos Derivative; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Our (-)-1,13-Bis[Di(4-Methylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Tol-Skp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and specific rotation measurement to ensure identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Specific Rotation [α]D20	Contact for details
Moisture (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.