Description

(1-Methyl-Azetidin-3-Yl)-Acetonitrile is a versatile and high-purity nitrile-functionalized azetidine building block essential for advanced organic synthesis. This compound matters because it provides a critical scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Research: Used in the design and development of new herbicides, fungicides, and insecticides, leveraging the azetidine ring's bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	(1-Methyl-Azetidin-3-Yl)-Acetonitrile
CAS No.	1545354-19-5
Molecular Formula	C6H10N2
Molecular Weight	110.16 g/mol
Synonyms	1-Methyl-3-(cyanomethyl)azetidine; 3-(Cyanomethyl)-1-methylazetidine; 1-Methylazetidine-3-acetonitrile; Azetidine, 1-methyl-3-(cyanomethyl)-; (1-Methylazetidin-3-yl)acetonitrile; 2-(1-Methylazetidin-3-yl)acetonitrile
EINECS	Contact for details

Quality Control

Our (1-Methyl-Azetidin-3-Yl)-Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.