Description

3-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated phenyl moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and in the development of new organometallic complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, leveraging its boronic ester and halogen functionalities.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes, benefiting from the handle provided by the bromomethyl group for further functionalization.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients in life sciences.

Basic Information

Product Name	3-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1544739-25-4
Molecular Formula	C13H17BBrFO2
Molecular Weight	315.99 g/mol
Synonyms	(3-(Bromomethyl)-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-3-(bromomethyl)benzeneboronic acid pinacol ester; (4-Fluoro-3-(bromomethyl)phenyl)boronic acid pinacol ester; Pinacol (3-(bromomethyl)-4-fluorophenyl)boronate; B-[3-(Bromomethyl)-4-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromomethyl-4-fluorobenzeneboronic acid pinacol ester; 1544739-25-4
EINECS	Contact for details

Quality Control

Our 3-Bromomethyl-4-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.