Description

4'-Bromo-2,2,2,2',5'-Pentafluoroacetophenone is a high-value, multi-fluorinated aromatic ketone building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its precise structure, featuring a bromine atom and multiple fluorine substituents, makes it a critical intermediate for synthesizing complex agrochemicals, pharmaceuticals, and specialty materials. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, anti-inflammatory, and antiviral applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms contribute to enhanced bioactivity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved charge transport, thermal stability, and emission properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying the effects of polyfluorination on molecular conformation, lipophilicity, and metabolic stability.
• Specialty Polymer Modifier: Used to incorporate fluorine into polymer backbones or side chains, enhancing material properties such as chemical resistance, low surface energy, and optical clarity.

Basic Information

Product Name	4'-Bromo-2,2,2,2',5'-Pentafluoroacetophenone
CAS No.	1540160-13-1
Molecular Formula	C8H2BrF5O
Molecular Weight	288.99 g/mol
Synonyms	1-(4-Bromo-2,3,5,6-tetrafluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-bromo-2,3,5,6-tetrafluorophenyl)ethanone; 4'-Bromo-α,α,α,2',5'-pentafluoroacetophenone; Pentafluorobromoacetophenone; 4-Bromo-2,3,5,6-tetrafluoro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2,2,2,2',5'-Pentafluoroacetophenone is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, impurity profiles, and physical data. Our quality system is designed to support cGMP and ISO 9001 standards for traceability and consistency, making it suitable for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.