Description

tert-Butyl 3-(4-(2-Cyanoethynyl)Phenylcarbamoyl)Propylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors due to its functionalized aromatic and carbamate groups.
• Bioconjugation Chemistry: The cyanoethynyl group can be utilized for click chemistry or other bio-orthogonal conjugation strategies in antibody-drug conjugate (ADC) research.
• Custom Synthesis & Scale-Up: Sourced by fine chemical manufacturers for custom synthesis projects and process development from milligram to kilogram scale.

Basic Information

Product Name	tert-Butyl 3-(4-(2-Cyanoethynyl)Phenylcarbamoyl)Propylcarbamate
CAS No.	1539292-60-8
Molecular Formula	C20H23N3O3
Molecular Weight	353.42 g/mol
Synonyms	Boc-3-APC-CEP; tert-Butyl N-[3-[[4-(2-cyanoethynyl)phenyl]carbamoyl]propyl]carbamate; 3-((4-(2-Cyanoethynyl)phenyl)carbamoyl)propylcarbamic acid tert-butyl ester; 1-Boc-3-(4-(2-cyanoethynyl)phenylcarbamoyl)propylamine; N-Boc-3-((4-(2-cyanoethynyl)phenyl)carbamoyl)propan-1-amine; Carbamic acid, N-[3-[[4-(2-cyanoethynyl)phenyl]amino]carbonyl]propyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-(2-Cyanoethynyl)Phenylcarbamoyl)Propylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.