Description

Carboxyrhodamine 110-Peg3-Azide is a specialized fluorescent labeling reagent designed for bioorthogonal click chemistry applications. This compound is critical for researchers and developers who require precise, covalent tagging of biomolecules in complex biological systems without interfering with native biochemical processes. It is primarily utilized in the life sciences sector for advanced applications in bioconjugation, cellular imaging, and the development of diagnostic assays and targeted therapeutics.

Application

• Bioconjugation and Probe Synthesis: Used as a key reagent for site-specifically labeling antibodies, proteins, peptides, and oligonucleotides via copper-free click chemistry with alkyne-functionalized targets.
• Live-Cell Imaging and Tracking: Enables real-time visualization and tracking of cellular processes, receptor dynamics, and drug delivery pathways due to its bright green fluorescence and cell permeability.
• Diagnostic Assay Development: Serves as a high-sensitivity fluorescent tag in the development of ELISA, flow cytometry, and immunohistochemistry (IHC) kits for research and clinical diagnostics.
• Polymer and Materials Science: Incorporated into hydrogels, nanoparticles, and other polymeric materials to create functional, traceable biomaterials for tissue engineering and drug delivery systems.
• Proteomics and Biomarker Discovery: Facilitates the labeling and enrichment of specific protein populations for mass spectrometry analysis and biomarker identification.
• In Vivo Imaging Studies: Applied in preclinical research for non-invasive optical imaging in small animal models to study disease progression and therapeutic efficacy.

Basic Information

Product Name	Carboxyrhodamine 110-Peg3-Azide
CAS No.	1536327-95-3
Molecular Formula	C41H47N7O11
Molecular Weight	813.86 g/mol
Synonyms	5(6)-Carboxy-X-rhodamine 110-PEG3-Azide; CR110-PEG3-N3; 5/6-CR110-PEG3-Azide; Carboxyrhodamine 110 Triethylene Glycol Azide; 6-Carboxy-2',4,5,7-tetramethylrhodamine-PEG3-azide; Rhodamine 110 C5-PEG3-azide; TAMRA-PEG3-Azide derivative (Note: TAMRA is a common misnomer for tetramethyl rhodamine derivatives); Azido-PEG3-carboxyrhodamine 110
EINECS	Contact for details

Quality Control

Our Carboxyrhodamine 110-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and functional validation in click chemistry reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance data is provided with every shipment to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Red to purple solid or powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content	≤ 1.0% (KF)
Functional Performance	≥ 90% conjugation efficiency with model alkyne

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.