Description

3,3-Difluoro-2-Oxopent-4-Enoic Acid is a high-value fluorinated building block and synthon in advanced organic synthesis. Its unique structure, featuring both a difluorinated carbon center and an α,β-unsaturated keto-acid moiety, makes it a versatile precursor for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, leveraging the fluorine atom's ability to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the difluoro motif can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced materials with unique surface properties or stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and labeled compounds for studying biological mechanisms and diagnostics.
• Organic Synthesis Reagent: Acts as a versatile electrophile or Michael acceptor in complex organic transformations, including cycloadditions and conjugate additions.

Basic Information

Product Name	3,3-Difluoro-2-Oxopent-4-Enoic Acid
CAS No.	1535214-59-5
Molecular Formula	C5H4F2O3
Molecular Weight	150.08 g/mol
Synonyms	3,3-Difluoro-2-oxopent-4-enoic acid; 4-Pentenoic acid, 3,3-difluoro-2-oxo-; 3,3-Difluoro-2-oxo-4-pentenoic acid; DFOPA; (Z/E)-3,3-Difluoro-2-oxopent-4-enoic acid (mixture of isomers)
EINECS	Contact for details

Quality Control

Every batch of 3,3-Difluoro-2-Oxopent-4-Enoic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as NMR, HPLC, and GC is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is sensitive to strong alkalis and fluorides; keep away from incompatible substances. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.