Description

2-Fluoro-6-Hydroxybenzeneboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is specifically engineered to provide enhanced stability and reactivity in cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical development. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality precursors for Suzuki-Miyaura couplings and other complex syntheses.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality offers superior handling and stability compared to the free acid, facilitating efficient carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the synthesis of complex organic ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Probe Development: Useful for creating fluorinated molecular probes and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	2-Fluoro-6-Hydroxybenzeneboronic Acid Pinacol Ester
CAS No.	1534369-41-9
Molecular Formula	C₁₂H₁₆BFO₃
Molecular Weight	238.07 g/mol
Synonyms	2-Fluoro-6-hydroxybenzeneboronic acid pinacol ester; (2-Fluoro-6-hydroxyphenyl)boronic acid pinacol ester; 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2-(2-Fluoro-6-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-Fluoro-6-hydroxyphenyl)boronate; 1534369-41-9; 2-Fluoro-6-hydroxy phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Hydroxybenzeneboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.