Description

Bis-Peg6-Nhs Ester CAS NO 1526718-98-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) crosslinker featuring NHS ester groups at both termini. This compound is engineered for efficient and stable conjugation to primary amines, enabling the creation of well-defined, water-soluble bioconjugates and materials. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostics, and advanced material science who require reliable, reproducible, and site-specific coupling strategies.

Application

• Bioconjugation and Protein Modification: For creating stable PEGylated proteins, antibodies, and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Diagnostic Assay Development: Used to conjugate enzymes, fluorescent dyes, or other reporter molecules to antibodies or antigens in ELISA, lateral flow, and other immunoassay formats.
• Hydrogel and Biomaterial Synthesis: Serves as a crosslinking agent for amine-containing polymers (e.g., chitosan, gelatin) to form hydrogels for drug delivery, tissue engineering, and 3D cell culture scaffolds.
• Surface Functionalization: For modifying amine-coated surfaces, nanoparticles, or magnetic beads to introduce PEG spacers for reduced non-specific binding and further functional group attachment.
• Antibody-Drug Conjugate (ADC) Linker Exploration: Acts as a model or component in the development of cleavable or non-cleavable linker systems for targeted cancer therapies.
• Oligonucleotide Labeling: Facilitates the attachment of amine-modified DNA or RNA strands to various probes, solid supports, or carrier proteins.

Basic Information

Product Name	Bis-Peg6-Nhs Ester
CAS No.	1526718-98-8
Molecular Formula	C32H54N4O18
Molecular Weight	782.79 g/mol
Synonyms	Bis(NHS)PEG6; Bis(succinimidyl) hexaethylene glycol; Bis-NHS-PEG6; NHS-PEG6-NHS; Hexaethylene glycol bis(succinimidyl succinate); Succinimidyl ester of PEG6 diacid; 1,11-Bis[(2,5-dioxopyrrolidin-1-yl)oxy]-3,6,9-trioxaundecane-1,11-dione; PEG6 bis(N-hydroxysuccinimide ester)
EINECS	Contact for details

Quality Control

Our Bis-Peg6-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability, consistency, and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile; partially soluble in water (hydrolyzes)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.