Description

1,1-Difluorospiro[2.5]Octan-6-One CAS NO 1513853-81-0 is a specialized fluorinated spirocyclic ketone building block of significant interest in advanced organic synthesis. Its unique spirocyclic structure, combined with the difluoromethylene group, makes it a valuable precursor for creating complex molecular architectures with tailored physicochemical properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing spirocyclic cores found in bioactive molecules, potentially for central nervous system (CNS) or metabolic disease targets.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides where the difluorinated spiro structure can enhance stability and bioavailability.
• Material Science Precursor: Serves as a building block for advanced polymers or liquid crystals, where the rigid spiro center and fluorine atoms can influence thermal and optical properties.
• Fluorine Chemistry & Methodology Development: An important substrate for studying new fluorination reactions, ring-expansion chemistry, and the behavior of strained spiro systems.
• Ligand and Catalyst Design: The ketone functionality allows for derivatization into chiral ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	1,1-Difluorospiro[2.5]Octan-6-One
CAS No.	1513853-81-0
Molecular Formula	C8H10F2O
Molecular Weight	160.16 g/mol
Synonyms	1,1-Difluorospiro[2.5]octan-6-one; Spiro[2.5]octan-6-one, 1,1-difluoro-; 1,1-Difluoro-6-oxaspiro[2.5]octane (alternative naming); Difluorospirooctanone; 6-Oxo-1,1-difluorospiro[2.5]octane
EINECS	Contact for details

Quality Control

Our 1,1-Difluorospiro[2.5]Octan-6-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by GC/HPLC), identity confirmation (by IR, NMR), and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.