Description

3-(Trifluoromethyl)Cyclobutan-1-One is a high-value fluorinated cyclobutanone derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a strained four-membered ring and a highly electron-withdrawing trifluoromethyl group, enables the construction of complex molecules with enhanced metabolic stability and lipophilicity. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 group can improve biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystals, where the cyclobutanone ring can impart specific rigidity and thermal properties.
• Fluorine Chemistry Research: A valuable substrate for studying ring-opening reactions, strain-release chemistry, and the introduction of fluorinated motifs into complex architectures.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in metal-catalyzed reactions to create carbon-carbon bonds for complex molecule assembly.

Basic Information

Product Name	3-(Trifluoromethyl)Cyclobutan-1-One
CAS No.	1511981-13-7
Molecular Formula	C5H5F3O
Molecular Weight	138.09 g/mol
Synonyms	3-(Trifluoromethyl)cyclobutanone; 1-Cyclobutanone, 3-(trifluoromethyl)-; 3-Trifluoromethylcyclobutan-1-one; 3-(Trifluoromethyl)cyclobutanone; Trifluoromethylcyclobutanone; Cyclobutanone, 3-(trifluoromethyl)-; 1511981-13-7
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethyl)Cyclobutan-1-One is manufactured and tested under strict quality management protocols. Our products undergo rigorous analytical testing, including GC, HPLC, and NMR, to ensure compliance with the highest purity standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.