Description

2-(2-Fluoro-4-Methyl-5-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, ligand synthesis, and functional material development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex fluorinated and nitrated aromatic systems.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by introducing the functionalized aryl moiety into target molecules.
• Material Science Research: Serves as a monomer or building block for constructing organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to synthesize tagged molecules for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-(2-Fluoro-4-Methyl-5-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1510828-68-8
Molecular Formula	C₁₃H₁₇BFNO₄
Molecular Weight	281.09 g/mol
Synonyms	2-Fluoro-4-methyl-5-nitrophenylboronic acid pinacol ester; (2-Fluoro-4-methyl-5-nitrophenyl)boronic acid pinacol ester; 5-Nitro-2-fluoro-4-methylbenzeneboronic acid pinacol ester; Pinacol (2-fluoro-4-methyl-5-nitrophenyl)boronate; 2-(2-Fluoro-4-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1510828-68-8; Boronic acid, B-(2-fluoro-4-methyl-5-nitrophenyl)-, 1,1,1,3,3,3-hexamethyl-2-(2-fluoro-4-methyl-5-nitrophenyl)-2-borata-1,3-dioxane-4,6-dione (cyclic ester)
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-4-Methyl-5-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as boronic esters can be sensitive to moisture and prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.