Description

Tat-Gap19 CAS NO 1507930-54-2 is a synthetic peptide compound designed as a potent and selective inhibitor of connexin 43 (Cx43) hemichannels. This compound is critical for researchers and developers targeting cellular communication pathways, offering a high-purity tool for investigating gap junction and hemichannel function. It is primarily utilized in advanced life science research, pharmaceutical development for cardiac and neurological conditions, and as a key reference standard in bioanalytical studies.

Application

• Cardiovascular Research: Investigation of cardiac arrhythmias, ischemia-reperfusion injury, and myocardial infarction models by modulating Cx43 hemichannel activity.
• Neuroscience Studies: Research into neuroinflammation, stroke, epilepsy, and neurodegenerative diseases where aberrant hemichannel opening is implicated.
• Oncology Research: Exploration of tumor progression, metastasis, and the tumor microenvironment by targeting gap junction intercellular communication (GJIC).
• Wound Healing & Dermatology: Study of skin regeneration, chronic wound models, and inflammatory skin disorders.
• Pharmaceutical Development: Serves as a lead compound or reference standard in drug discovery programs for hemichannel modulators.
• Biochemical Assays: Used as a selective inhibitor in in vitro and ex vivo experimental protocols to validate Cx43-specific pathways.

Basic Information

Product Name	Tat-Gap19
CAS No.	1507930-54-2
Molecular Formula	C81H138N28O23S
Molecular Weight	1888.2 g/mol
Synonyms	TAT-Gap19; TAT-GAP19; TatGap19; Connexin 43 Inhibitor, TAT-Gap19; Cx43 Hemichannel Blocker TAT-Gap19; GRKKRRQRRRPPQYKLVGDCANVKQAK; HIV-1 TAT (48-60)-Gap19; Cell-Permeable Gap19 Peptide
EINECS	Contact for details

Quality Control

Every batch of Tat-Gap19 is manufactured under stringent conditions and undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. Our quality system adheres to cGMP guidelines for research-grade peptides. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for HPLC purity, amino acid analysis, mass spectrometry (MS), and peptide content.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below in a dry environment. For long-term storage, consider -80°C. Once reconstituted in a suitable sterile buffer, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ± 10% of theoretical
Water Content (K.F.)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.