Description

2-Bromo-1,3-Difluoro-4-Methoxybenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists in fine chemical, pharmaceutical R&D, and material science industries seeking to introduce specific fluorine and bromine motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the difluoro-methoxy-bromo aryl core imparts desired biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic materials, enhancing properties like dielectric anisotropy and electron transport.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the formation of new carbon-carbon and carbon-heteroatom bonds.
• Functionalized Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and material chemistry.

Basic Information

Product Name	2-Bromo-1,3-Difluoro-4-Methoxybenzene
CAS No.	1507082-29-2
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-2,4-Difluoro-5-Methoxybenzene; 4-Methoxy-2,6-Difluorobromobenzene; 2,6-Difluoro-4-Methoxybromobenzene; 5-Bromo-2,4-Difluoroanisole; Benzene, 2-bromo-1,3-difluoro-4-methoxy-; 2-Bromo-1,3-difluoro-4-methoxy-benzene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1,3-Difluoro-4-Methoxybenzene is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards, and a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.