Description

n-Acetyl-6-Azido-L-Norleucine is a specialized, non-natural amino acid derivative featuring a reactive azido group. This compound is a critical building block in chemical biology and pharmaceutical research, enabling the site-specific modification of biomolecules via bioorthogonal click chemistry. It is primarily utilized by researchers and process development scientists in the fields of bioconjugation, proteomics, and novel therapeutic development, where precise labeling and functionalization are required.

Application

• Bioconjugation Reagent: Used for the site-specific labeling of proteins, antibodies, and peptides via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) click reactions.
• Chemical Biology Probes: Serves as a key intermediate in the synthesis of activity-based probes (ABPs) and photoaffinity labels for studying enzyme function and protein-protein interactions.
• Proteomics Research: Incorporated into peptides or proteins for mass spectrometry-based identification, enrichment, and profiling studies.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the controlled attachment of cytotoxic payloads to antibodies through stable triazole linkages.
• Material Science Functionalization: Enables the surface modification of polymers, nanoparticles, and hydrogels with bioactive peptides.
• Pharmaceutical Intermediate: Acts as a precursor in the synthesis of more complex molecules with potential therapeutic applications.

Basic Information

Product Name	n-Acetyl-6-Azido-L-Norleucine
CAS No.	1505525-07-4
Molecular Formula	C8H14N4O3
Molecular Weight	214.22 g/mol
Synonyms	N-α-Acetyl-6-azido-L-norleucine; (2S)-2-Acetamido-6-azidohexanoic acid; Ac-6Azido-L-Nle-OH; 6-Azido-L-norleucine N-acetyl derivative; L-Norleucine, N-acetyl-6-azido-; N-Acetyl-6-azidonorleucine; Azido-functionalized amino acid derivative; Click chemistry amino acid
EINECS	Contact for details

Quality Control

Our n-Acetyl-6-Azido-L-Norleucine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support custom synthesis and purity grades (including >95%, >98%, and >99%) to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.