Description

3-[4-(Difluoromethoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is a sophisticated, high-purity chemical building block designed for advanced research and synthesis. This compound is critical for the development of novel pharmaceuticals and bioactive molecules, particularly in peptide chemistry and medicinal chemistry applications. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: Employed in the development of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Protecting Group Chemistry: The Fmoc (9-fluorenylmethoxycarbonyl) group is a standard for temporary amine protection in multi-step organic synthesis.
• Fine Chemical Synthesis: A versatile intermediate for creating specialized compounds with difluoromethoxy and aromatic functionalities.

Basic Information

Product Name	3-[4-(Difluoromethoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid
CAS No.	1496564-27-2
Molecular Formula	C25H21F2NO5
Molecular Weight	453.44 g/mol
Synonyms	Fmoc-4-(Difluoromethoxy)-L-phenylalanine; Fmoc-4-(Difluoromethoxy)-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(difluoromethoxy)-L-phenylalanine; 4-(Difluoromethoxy)-L-phenylalanine, N-Fmoc derivative; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-[4-(difluoromethoxy)phenyl]propanoic acid; Fmoc-L-4-(Difluoromethoxy)Phe-OH; Fmoc-4-(OCHF2)-Phe-OH; Fmoc-4-(Difluoromethoxy)-DL-phenylalanine (racemic mixture)
EINECS	Contact for details

Quality Control

Our production of 3-[4-(Difluoromethoxy)Phenyl]-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.