Description

6-Bromo-5-(trifluoromethyl)nicotinonitrile is a high-value, multi-functional heterocyclic building block. This compound is strategically important for introducing both bromo and trifluoromethyl substituents onto a pyridine core, enabling advanced molecular design. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the trifluoromethyl and bromo groups.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed as a probe or linker in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex biaryl structures.
• Fluorine Chemistry: Acts as a valuable synthon for introducing the metabolically stable and lipophilic trifluoromethyl group into target molecules.

Basic Information

Product Name	6-Bromo-5-(trifluoromethyl)nicotinonitrile
CAS No.	1496535-09-1
Molecular Formula	C7H2BrF3N2
Molecular Weight	251.01 g/mol
Synonyms	6-Bromo-5-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-6-bromo-5-(trifluoromethyl)pyridine; 6-Bromo-5-trifluoromethylnicotinonitrile; 5-(Trifluoromethyl)-6-bromonicotinonitrile; 2-Bromo-3-cyano-5-(trifluoromethyl)pyridine; Nicotinonitrile, 6-bromo-5-(trifluoromethyl)-; Pyridine, 3-cyano-6-bromo-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-(trifluoromethyl)nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.