Description

1-Bromo-2-Fluoro-4-Isobutoxybenzene is a high-purity halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides with enhanced efficacy and selectivity.
• Liquid Crystal Materials: Serves as a core building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Catalyst Ligand Precursor: Functionalized to create sophisticated phosphine or nitrogen-based ligands for transition metal catalysis.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions in academic and industrial R&D settings.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-Isobutoxybenzene
CAS No.	1496272-53-7
Molecular Formula	C10H12BrFO
Molecular Weight	247.11 g/mol
Synonyms	2-Fluoro-4-isobutoxy-1-bromobenzene; 4-Isobutoxy-2-fluorobromobenzene; Benzene, 1-bromo-2-fluoro-4-(2-methylpropoxy)-; 1-Bromo-2-fluoro-4-(2-methylpropoxy)benzene; 1-Bromo-2-fluoro-4-isobutyloxybenzene; 4-Bromo-3-fluorophenyl isobutyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4-Isobutoxybenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and aligns with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.