Description

(7,7-Difluorobicyclo[4.1.0]heptan-3-yl)methanol is a high-value, functionalized bicyclic building block featuring a strained cyclopropane ring and fluorinated substituents. This compound is critical for advanced organic synthesis, offering unique reactivity and the ability to modulate the physicochemical properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, drug discovery, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated, three-dimensional structural motifs that can enhance metabolic stability and binding affinity.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorocyclopropane unit can impart favorable biological activity and environmental profile.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored thermal and chemical resistance properties.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging its rigid, three-dimensional scaffold.
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the stereoelectronic effects of gem-difluoro groups on strained ring systems.
• Chemical Biology Probes: Utilized to create molecular probes for investigating biological pathways, where the fluorine atoms can serve as tags for 19F NMR spectroscopy.

Basic Information

Product Name	(7,7-Difluorobicyclo[4.1.0]heptan-3-yl)methanol
CAS No.	1494594-77-2
Molecular Formula	C8H12F2O
Molecular Weight	162.18 g/mol
Synonyms	3-(Hydroxymethyl)-7,7-difluorobicyclo[4.1.0]heptane; (7,7-Difluoronorcaranyl)methanol; 7,7-Difluoro-3-bicyclo[4.1.0]heptanemethanol; 3-Hydroxymethyl-7,7-difluorobicyclo[4.1.0]heptane; 7,7-Difluoro-3-norcaranemethanol; Bicyclo[4.1.0]heptane-3-methanol, 7,7-difluoro-
EINECS	Contact for details

Quality Control

Our (7,7-Difluorobicyclo[4.1.0]heptan-3-yl)methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.